Infectivity and cross-immunity studies of Theileria lestoquardi and Theileria annulata in sheep and cattle: I. In vivo responses
Identifieur interne : 001171 ( Main/Exploration ); précédent : 001170; suivant : 001172Infectivity and cross-immunity studies of Theileria lestoquardi and Theileria annulata in sheep and cattle: I. In vivo responses
Auteurs : Ingrid Leemans [Suède] ; Duncan Brown [Royaume-Uni] ; Parviz Hooshmand-Rad [Iran] ; Erol Kirvar [Royaume-Uni] ; Arvid Uggla [Suède]Source :
- Veterinary Parasitology [ 0304-4017 ] ; 1999.
English descriptors
- Teeft :
- Anatolicum, Annulata, Annulata antigen, Annulata infection, Annulata inoculation, Annulata schizont antigens, Annulata sporozoites, Antibody reactions, Antibody response, Antibody responses, Antibody test, Calves inoculated, Control sheep, Endpoint titres, Experimental infections, Haematological, Haematological parameters, Haematological parameters sheep number, Infection, Inoculated, Inoculation, Leemans, Lestoquardi, Lestoquardi antigen, Lestoquardi infection, Lestoquardi inoculation, Lestoquardi sporozoites, Lymph, Lymph node, Lymph node biopsies, Lymph node biopsy smears, Lymph nodes, Naive sheep, Node, Other hand, Parasitaemia, Parasite, Parasite species, Parasitological, Parasitology, Peripheral blood, Piroplasm, Piroplasm detection peak piroplasm parasitaemia fall, Primary infection, Primary inoculation, Schizont, Schizont detection, Schizonts, Sheep, Sporozoite, Sporozoite stabilates, Theileria, Theileria annulata, Theileria hirci, Theileria lestoquardi, Theileria species, Theileriosis, Titre, Tropical theileriosis, Veterinary parasitology.
Abstract
Abstract: In a series of experiments, sporozoite stabilates of a Theileria lestoquardi (Lahr) and a T. annulata (Ankara) stock prepared from Hyalomma anatolicum anatolicum ticks, were used to examine the infectivity of both parasite species for sheep and cattle and to study the development of cross-immunity between these parasite species. In the first experiment sheep and cattle were inoculated with T. lestoquardi sporozoites. Surviving animals and naive sheep and cattle were, in the second experiment, inoculated with T. annulata. In the third experiment, naive sheep and sheep previously infected with T. annulata, were inoculated with T. lestoquardi. The following responses to inoculations were monitored: clinical and haematological signs of infection, appearance of parasitic stages of the parasites in lymph node biopsies and in peripheral blood and serological response to T. lestoquardi and T. annulata schizont antigens. While T. lestoquardi readily infected sheep and caused severe disease, it did not infect cattle. On the other hand, T. annulata infected both cattle and sheep. However, whereas cattle became severely affected, infected sheep showed mild clinical symptoms only and piroplasms did not develop. Despite their different behaviour in the host species examined, cross-immunity studies suggested that the parasite species are very closely related. Experiments in sheep indicated that T. lestoquardi infection protected against subsequent T. annulata infection. On the other hand, recovery from T. annulata infection did not prevent infection by sporozoites of T. lestoquardi, resulting in the establishment of schizonts and their subsequent development into piroplasms, although it protected against the major clinical effects of T. lestoquardi infection.
Url:
DOI: 10.1016/S0304-4017(99)00013-8
Affiliations:
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Box 11365-1558, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Kirvar, Erol" sort="Kirvar, Erol" uniqKey="Kirvar E" first="Erol" last="Kirvar">Erol Kirvar</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian, Scotland EH25 9RG</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Uggla, Arvid" sort="Uggla, Arvid" uniqKey="Uggla A" first="Arvid" last="Uggla">Arvid Uggla</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Parasitology, Swedish University of Agricultural Sciences and National Veterinary Institute, P.O. Box 7073, SE-750 07, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Veterinary Parasitology</title><title level="j" type="abbrev">VETPAR</title><idno type="ISSN">0304-4017</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="179">179</biblScope><biblScope unit="page" to="192">192</biblScope></imprint><idno type="ISSN">0304-4017</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-4017</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Anatolicum</term><term>Annulata</term><term>Annulata antigen</term><term>Annulata infection</term><term>Annulata inoculation</term><term>Annulata schizont antigens</term><term>Annulata sporozoites</term><term>Antibody reactions</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody test</term><term>Calves inoculated</term><term>Control sheep</term><term>Endpoint titres</term><term>Experimental infections</term><term>Haematological</term><term>Haematological parameters</term><term>Haematological parameters sheep number</term><term>Infection</term><term>Inoculated</term><term>Inoculation</term><term>Leemans</term><term>Lestoquardi</term><term>Lestoquardi antigen</term><term>Lestoquardi infection</term><term>Lestoquardi inoculation</term><term>Lestoquardi sporozoites</term><term>Lymph</term><term>Lymph node</term><term>Lymph node biopsies</term><term>Lymph node biopsy smears</term><term>Lymph nodes</term><term>Naive sheep</term><term>Node</term><term>Other hand</term><term>Parasitaemia</term><term>Parasite</term><term>Parasite species</term><term>Parasitological</term><term>Parasitology</term><term>Peripheral blood</term><term>Piroplasm</term><term>Piroplasm detection peak piroplasm parasitaemia fall</term><term>Primary infection</term><term>Primary inoculation</term><term>Schizont</term><term>Schizont detection</term><term>Schizonts</term><term>Sheep</term><term>Sporozoite</term><term>Sporozoite stabilates</term><term>Theileria</term><term>Theileria annulata</term><term>Theileria hirci</term><term>Theileria lestoquardi</term><term>Theileria species</term><term>Theileriosis</term><term>Titre</term><term>Tropical theileriosis</term><term>Veterinary parasitology</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: In a series of experiments, sporozoite stabilates of a Theileria lestoquardi (Lahr) and a T. annulata (Ankara) stock prepared from Hyalomma anatolicum anatolicum ticks, were used to examine the infectivity of both parasite species for sheep and cattle and to study the development of cross-immunity between these parasite species. In the first experiment sheep and cattle were inoculated with T. lestoquardi sporozoites. Surviving animals and naive sheep and cattle were, in the second experiment, inoculated with T. annulata. In the third experiment, naive sheep and sheep previously infected with T. annulata, were inoculated with T. lestoquardi. The following responses to inoculations were monitored: clinical and haematological signs of infection, appearance of parasitic stages of the parasites in lymph node biopsies and in peripheral blood and serological response to T. lestoquardi and T. annulata schizont antigens. While T. lestoquardi readily infected sheep and caused severe disease, it did not infect cattle. On the other hand, T. annulata infected both cattle and sheep. However, whereas cattle became severely affected, infected sheep showed mild clinical symptoms only and piroplasms did not develop. Despite their different behaviour in the host species examined, cross-immunity studies suggested that the parasite species are very closely related. Experiments in sheep indicated that T. lestoquardi infection protected against subsequent T. annulata infection. On the other hand, recovery from T. annulata infection did not prevent infection by sporozoites of T. lestoquardi, resulting in the establishment of schizonts and their subsequent development into piroplasms, although it protected against the major clinical effects of T. lestoquardi infection.</div></front></TEI><affiliations><list><country><li>Iran</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Écosse</li></region><settlement><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li></orgName></list><tree><country name="Suède"><noRegion><name sortKey="Leemans, Ingrid" sort="Leemans, Ingrid" uniqKey="Leemans I" first="Ingrid" last="Leemans">Ingrid Leemans</name></noRegion><name sortKey="Uggla, Arvid" sort="Uggla, Arvid" uniqKey="Uggla A" first="Arvid" last="Uggla">Arvid Uggla</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Brown, Duncan" sort="Brown, Duncan" uniqKey="Brown D" first="Duncan" last="Brown">Duncan Brown</name></region><name sortKey="Kirvar, Erol" sort="Kirvar, Erol" uniqKey="Kirvar E" first="Erol" last="Kirvar">Erol Kirvar</name></country><country name="Iran"><noRegion><name sortKey="Hooshmand Rad, Parviz" sort="Hooshmand Rad, Parviz" uniqKey="Hooshmand Rad P" first="Parviz" last="Hooshmand-Rad">Parviz Hooshmand-Rad</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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